The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention.
Pseudomonas aeruginosa is an opportunistic nosocomial pathogen with high rates of morbidity and mortality in infected patients [1]. The impacts of bacterial efflux and permeability on inhibitory potency were determined using isogenic panels of KPC-3-producing isogenic strains of Print 2020 May 21.Nelson K, Rubio-Aparicio D, Sun D, Dudley M, Lomovskaya O.Antimicrob Agents Chemother. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. 2013 Jul;8(7):901-21. doi: 10.2217/fmb.13.57.Price KE, Orazi G, Ruoff KL, Hebert WP, O'Toole GA, Mastoridis P.PLoS One.
2020 May 6;10(5):720. doi: 10.3390/biom10050720. doi: 10.1016/j.biotechadv.2018.11.013.
Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals.
2020 May 25;11:806. doi: 10.3389/fmicb.2020.00806. 2018 Apr;58(4):428-439. doi: 10.1165/rcmb.2017-0321TR.Ciofu O, Tolker-Nielsen T, Jensen PØ, Wang H, Høiby N.Adv Drug Deliv Rev. 2020 May 21;64(6):e00212-20. 2020 May 21;64(6):e00130-20. COVID-19 is an emerging, rapidly evolving situation. Car-bapenems such as imipenem and meropenem are the major antibiotics used for treatment of P. aeruginosa infections (2,3). Epub 2017 Jul 19.EXCLI J. Pseudomonas aeruginosa is intrinsically resistant to many antimicrobial drugs, making carbapenems crucial in clinical management. Unable to load your delegates due to an error Background: Pseudomonas aeruginosa is a pathogenic bacterium, causing nosocomial infections with intrinsic and acquired resistance mechanisms to a large group of antibiotics, including β-lactams. 2018 Jan;78(1):65-98. doi: 10.1007/s40265-017-0851-9.Biomolecules. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. Epub 2014 Dec 2.Jakobsen TH, Bjarnsholt T, Jensen PØ, Givskov M, Høiby N.Future Microbiol. Pseudomonas aeruginosa is a common encapsulated, Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans. In recent years, carbapenem resis-tance has developed among P. aeruginosa … This site needs JavaScript to work properly. 2020 Jun 17;19:813-816. doi: 10.17179/excli2020-1249. Together with the production of AmpC and MexAB-OprM, these strategies largely contribute to the low basal susceptibility of P. aeruginosa to antibiotics. Unable to load your collection due to an error
level of intrinsic resistance to antimicrobial drugs and has potential to acquire resistance (2,3). In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. HighWire COVID-19 is an emerging, rapidly evolving situation.
The main intrinsic resistance feature in P. aeruginosa is its low outer membrane permeability, which is ∼12–100-fold lower than that reported for E. coli (Hancock, 1998). Foremost among the mechanisms of resistance in both of these pathogens is the production of β-lactamases and aminoglycoside-modifying enzymes. Treatment is challenging due to the presence of intrinsic antimicrobial resistance genes and the organism’s ability to acquire genes encoding multiple resistance … doi: 10.1128/AAC.00212-20. Please enable it to take advantage of the complete set of features! eCollection 2020.
Name must be less than 100 characters eCollection 2020.Ocampo-Ibáñez ID, Liscano Y, Rivera-Sánchez SP, Oñate-Garzón J, Lugo-Guevara AD, Flórez-Elvira LJ, Lesmes MC.Evol Bioinform Online. Please enable it to take advantage of the complete set of features! Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas Aeruginosa, and Acinetobacter Baumannii HighWire
This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice. An example of intrinsic resistance is the resistance of Pseudomonas aeruginosa (a common cause of lung infections in people with cystic fibrosis) to most ß-lactam antibiotics. doi: 10.1371/journal.pone.0141192. Elsevier Science
Am J Respir Cell Mol Biol. Unable to load your collection due to an error
Clipboard, Search History, and several other advanced features are temporarily unavailable. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. Published by Elsevier Inc. All rights reserved. Free PMC article 2020 Jul 22;64(8):e00757-20. doi: 10.1128/AAC.00130-20.
Name must be less than 100 characters 2020 Jun 3;11:1048. doi: 10.3389/fimmu.2020.01048. 2017 Sep;307(6):353-362. doi: 10.1016/j.ijmm.2017.07.004.
Therefore, transfer to the products is favored during manufacture, being also enhanced by their resistance to the preservatives used.