On the molecular level, we work with the Zerial lab to understand how self-organization flows lead to domain formation on endosome membranes that generate the mechanical forces for tethering and fusion of organelles.
We coordinate the interdisciplinary and international Hyman Lab Follow. We exclusively enroll PhD students though the The IMPRS-CellDevoSys PhD Program, which runs a track in Computational Biology for graduates of computer science, computational science, mathematics, physics, and engineering. The biological phenomena considered are flows in the We aim to enable the next step for computational biology: Discovering the decision and communication patterns cells execute when arranging into tissues is a reverse-engineering task. Artists and architects of all eras have been inspired by symmetry in nature. Jochen Rink from the Max Planck Institute of Molecular Cell Biology grill@mpi-cbg.de. The Max-Planck researchers might have found the answer: The cytoplasm of the seemingly dead cells changes its consistency from liquid to solid, thereby protecting the sensitive structures in the cellular interior. Zerial Lab, MPI-CBG, Pfotenhauerstrasse 108, 01307 Dresden, GERMANY. How does a cell know along which direction to divide to form a well-structured tissue and not just a clump of cells? In order to perform diverse functions, the cell`s proteins and RNAs are located in membraneous compartiments, but also as distinct condensates. Stephan W Grill Max Planck Institute of Molecular Cell Biology and Genetics Verified email at mpi-cbg.de. How cells switch on and off this stand-by mode is unknown. Max Planck Institute for Molecular Cell Biology and Genet-ics and Max Planck Institute for the Physics of Complex Sys-tems, Dresden 01307, Germany. The Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, PhD student and/or postdoctoral candidate in Computational Biology 1. All simulations include either fluid flow or active mechanics. Stephan Grill (MPI-CBG & BIOTEC / TU Dresden) Biophysics. Welcome to the MPI-CBG Intranet The Max Planck Society (MPS) has created a new Intranet called “MAX” and we are one of the institutes selected to participate in the pilot. Many biomolecules move through cells like microscopic machines. Dr. Jan Brugues (MPI-CBG) Prof. Dr. Stephan Grill (BIOTEC, TU Dresden) Ph.D. Therefore, it is a promising tool for drug development to test and predict the effects of pharmacological compounds on the liver. Email: zerial@mpi-cbg.de He uses optical tweezers to pull gently on DNA strands. Frank Jülicher (MPI-PKS) Biological physics. They function out of thermodynamic equilibrium and continuously use metabolic pathways to obtain energy from chemical bonds derived from nutrients to fulfill the systems energetic requirements to stay alive, grow, and develop. We have now uncovered a protein sequence encoded molecular grammar that underlies phase separation of some types of proteins inside cells. Eugene W. Myers never attended a biology lecture. The research team is now working on a strategy to calibrate this model to human biliary fluid dynamics. These are particularly challenging phenomena for which new simulation methods are required. The cilium, an antenna-like structure in the cell, undergoes rapid assembly and disassembly. website. To do this he studies For the latter, black-box optimization and design-centering algorithms are crucial.A current focus is on understanding the role of fluid flow and active cytoskeletal forces in growth and development. First six reference-quality bat genomes released and analysed. Particles are used as collocation points to represent continuous fields. On the tissue level, we work with the Zerial lab to simulate bile flow in mouse liver in order to study its role during growth and regeneration. This is enabled by a bidirectional train-like transport system called intraflagellar transport (IFT). Science and fun from the lab of Tony Hyman at the MPI-CBG.
In our case, this includes accelerators like graphics cards for visualization, and computer clusters for image analysis and simulations. Wieland B. Huttner, em. Model organisms like the fruit fly, zebrafish, roundworm or mouse help the 28 research groups to find answers to the very basic questions of life.
Research Council ERC awards grants of up to 2.5 million euros each
The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) is a biology research institute located in Dresden, Germany.It was founded in 1998 and was fully operational in 2001. A theory (In addition to predictive forward simulations, reverse-engineering the “algorithms of tissue formation” also requires real-time microscopy, so that we are able to directly overlay simulation results with observations and tune the former using guided black-box optimization algorithms.A mid-term goal of ours is the development of immersive virtual-reality visualization and hand gesture control for 3D microscopy.